My research integrates the disciplines of T cell biology and clinical immunology to gain new and fundamental understanding of human diseases and developing better immunotherapeutic strategies. This involves the study and characterization of T cell responses, against several emergent pathogens relevant to worldwide global health, such as whooping cough (pertussis), COVID-19, dengue, and common allergens that cause allergic asthma. I have a strong track record of studying vaccine responses and developing new approaches and innovative ways to measure biological processes such as the establishment of a T cell-based immunodiagnostic system to distinguish SARS-CoV-2 infection and COVID-19 vaccination history and the development of a Bordetella pertussis genome-wide epitope screening strategy.
In particular, my focus in pertussis research led to several seminal contributions such as exploring how differences in T cell responses contribute to the time-dependent decline in protection by the acellular pertussis vaccine and the observation that asymptomatic infections are highly prevalent in human vaccinated populations. These studies also established me as a recognized leader in the field of pertussis adaptive immunity.